Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease
نویسندگان
چکیده
منابع مشابه
Bioactive Flavonoids and Catechols as Hif1 and Nrf2 Protein Stabilizers - Implications for Parkinson’s Disease
Flavonoids are known to trigger the intrinsic genetic adaptive programs to hypoxic or oxidative stress via estrogen receptor engagement or upstream kinase activation. To reveal specific structural requirements for direct stabilization of the transcription factors responsible for triggering the antihypoxic and antioxidant programs, we studied flavones, isoflavones and catechols including dihydro...
متن کاملEvidence-based bioactive phytoconstituents for human health and disease prevention
The term “medicinal” as applied to a plant indicates that it contains a substance or substances which modulate beneficially the physiology of sick mammals. Thousands of species of higher plants have been used by man for that purpose. Modern techniques have revealed the enormous variety and complexity of so-called secondary plant chemicals, i.e., those which do not occur in all species, but whic...
متن کاملEvidence-based bioactive phytoconstituents for human health and disease prevention
The term “medicinal” as applied to a plant indicates that it contains a substance or substances which modulate beneficially the physiology of sick mammals. Thousands of species of higher plants have been used by man for that purpose. Modern techniques have revealed the enormous variety and complexity of so-called secondary plant chemicals, i.e., those which do not occur in all species, but whic...
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Few changes have occurred in the use of various stabilizers over recent years. In the current literature, phosphate derivatives are used as anti-ageing additives in polymers, and the most popular of these are sterically hindering cyclic amines. However, most of these compounds are carcinogenic. Synthetic phenols have been increasingly used as antioxidants in food and in polymers. Ecological sta...
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Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting in part from loss of nigrostriatal dopamine (DA) neurons. Treatments act only to relieve symptoms. It is therefore essential to develop treatments that slow or reverse the neurodegenerative process. Here, I explored exercise as a potential treatment against a 6-hydroxydopamine (6-OHDA) rat model. 6-OHDA causes select...
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ژورنال
عنوان ژورنال: Aging and Disease
سال: 2016
ISSN: 2152-5250
DOI: 10.14336/ad.2016.0505